Is the anti-stress effect of vitamin C related to adrenal gland function in rat?

被引：6

作者：

Choi, Ji Young ^{[1
]}

dela Pena, Ike Campomayor ^{[1
]}

Yoon, Seo Young ^{[1
]}

Woo, Tae Sun ^{[1
]}

Choi, Yoon Jung ^{[1
]}

Shin, Chan Young ^{[3
]}

Ryu, Jong Hoon ^{[4
]}

Lee, Yong Soo ^{[5
]}

Yu, Gu Yong ^{[2
]}

Cheong, Jae Hoon ^{[1
]}

机构：

[1] Sahmyook Univ, Uimyung Res Inst Neurosci, Seoul 139742, South Korea

[2] Sahmyook Univ, Dept Chem, Seoul 139742, South Korea

[3] Konkuk Univ, Sch Med, Dept Pharmacol, Seoul 143701, South Korea

[4] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[5] Duksung Womens Univ, Sch Med, Dept Pharmacol, Seoul 132714, South Korea

来源：

FOOD SCIENCE AND BIOTECHNOLOGY | 2011年 / 20卷 / 02期

关键词：

vitamin C; electroshock stress; corticosterone; behavior; CORTICOTROPIN-RELEASING-FACTOR; ASCORBIC-ACID; CENTRAL AMYGDALA; FACTOR RECEPTORS; STRESS; ACTIVATION; BEHAVIOR; ANTAGONISM; ANXIETY; SYSTEM;

D O I：

10.1007/s10068-011-0060-3

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

The aim of this study was to investigate whether vitamin C influences the stress response system of the adrenal gland. Adrenalectomized (ADX) rats and non-ADX rats were administered vitamin C and were subjected to electroshock stress (ES) for 5 days. After loading the final stress, stress-related behaviors and corticosterone (CORT), vitamin C, and adrenocorticotropin-releasing hormone (ACTH) levels in the blood were measured. Vitamin C supplementation decreased CORT levels in non-ADX rats. Stress decreased the mean value of rearing frequency in both non-ADX and ADX rats, while vitamin C partially enhanced it only in non-ADX. Vitamin C supplementation decreased mean ACTH level in both groups. It also significantly decreased freezing time increased by stress. Lastly, vitamin C motivated both groups to cross over an electric field more frequently as compared to their respective control groups. These results suggest that the alleviating effect of vitamin C on stress-related rearing behavior was exerted via modulation of CORT, but its effect on freezing behavior may be attributed to corticotropin-releasing hormone (CRH) or ACTH.

引用

页码：429 / 435

页数：7

共 33 条

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Ascorbic acid administration produces an antidepressant-like effect: Evidence for the involvement of monoaminergic neurotransmission [J].