High-Dose Antiangiogenic Therapy for Glioblastoma: Less May Be More.?

被引：20

作者：

de Groot, John F. ^{[1
,2
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Unit 431, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA

来源：

CLINICAL CANCER RESEARCH | 2011年 / 17卷 / 19期

关键词：

PHASE-II; BEVACIZUMAB; GLIOMA; TEMOZOLOMIDE; INVASION; GROWTH;

D O I：

10.1158/1078-0432.CCR-11-1853

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Targeting angiogenesis in glioblastoma rapidly reduces vascular permeability and contrast enhancement on MRI and prolongs progression-free survival. The long-term efficacy of bevacizumab and other anti-angiogenic agents is limited, however, because of the rapid development of resistance. Alternative dosing approaches may be one mechanism of prolonging therapeutic efficacy. Clin Cancer Res; 17(19); 6109-11. (C) 2011 AACR.

引用

页码：6109 / 6111

页数：3

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