Vaccination against hydatidosis using a defined recombinant antigen

被引：182

作者：

Lightowlers, MW ^{[1
]}

Lawrence, SB ^{[1
]}

Gauci, CG ^{[1
]}

Young, J ^{[1
]}

Ralston, MJ ^{[1
]}

Maas, D ^{[1
]}

Heath, DD ^{[1
]}

机构：

[1] AGRES,WALLACEVILLE ANIM RES CTR,UPPER HUTT,NEW ZEALAND

来源：

PARASITE IMMUNOLOGY | 1996年 / 18卷 / 09期

关键词：

Echinococcus granulosus; hydatid; echinococcosis; vaccine; recombinant antigen;

D O I：

10.1111/j.1365-3024.1996.tb01029.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Echinococcus granulosus is the causative agent of hydatid disease in humans and animals. Natural transmission of the parasite occurs between dogs as definitive hosts and animal intermediate hosts. There is an la gent need for improved methods to control the parasite's transmission. Here we describe the development of a vaccine based on a cloned recombinant antigen from the parasite egg (oncosphere). Sheep vaccinated with the antigen, designated EG95, are protected (mean 96-98%) against hydatidosis developing from an experimental challenge infection with E. granulosus eggs. The vaccine will provide a valuable new tool to aid in control of transmission of this important human pathogen. It also has the potential to prevent hydatid disease directly through vaccination of humans.

引用

页码：457 / 462

页数：6

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