Bioactivity of Olive Oil Phenols in Neuroprotection

被引：183

作者：

Angeloni, Cristina ^{[1
]}

Malaguti, Marco ^{[2
]}

Barbalace, Maria Cristina ^{[2
]}

Hrelia, Silvana ^{[2
]}

机构：

[1] Univ Camerino, Sch Pharm, I-62032 Camerino, Italy

[2] Univ Bologna, Dept Life Qual Studies, Alma Mater Studiorum, I-40126 Bologna, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2017年 / 18卷 / 11期

关键词：

olive oil; tyrosol; hydroxytyrosol; oleuropein; oleocanthal; oxidative stress; neurodegeneration; Parkinson's disease; Alzheimer's disease; multiple sclerosis; SPINAL-CORD-INJURY; AMYOTROPHIC-LATERAL-SCLEROSIS; OXIDATIVE STRESS; MEDITERRANEAN DIET; PARKINSONS-DISEASE; OLEUROPEIN AGLYCONE; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; CELL-DEATH; COGNITIVE FUNCTION;

D O I：

10.3390/ijms18112230

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Neurological disorders such as stroke, Alzheimer's and Parkinson's diseases are associated with high morbidity and mortality, and few or no effective options are available for their treatment. These disorders share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, inflammation and apoptosis. A large body of evidence supports the beneficial effects of the Mediterranean diet in preventing neurodegeneration. As the Mediterranean diet is characterized by a high consumption of extra-virgin olive oil it has been hypothesized that olive oil, and in particular its phenols, could be responsible for the beneficial effect of the Mediterranean diet. This review provides an updated vision of the beneficial properties of olive oil and olive oil phenols in preventing/counteracting both acute and chronic neurodegenerative diseases.

引用

页数：27

共 210 条

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Olive-Oil-Derived Oleocanthal Enhances β-Amyloid Clearance as a Potential Neuroprotective Mechanism against Alzheimer's Disease: In Vitro and in Vivo Studies [J].