Tridemethylisovelleral, a potent cytotoxic agent

被引：17

作者：

Aujard, I

Röme, D

Arzel, E

Johansson, M

de Vos, D

Sterner, O

机构：

[1] Lund Univ, Dept Organ Chem, S-22100 Lund, Sweden

[2] Pharmachemie BV, Dept Med, NL-2003 RN Haarlem, Netherlands

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 22期

关键词：

tridemethylisovelleral; isovelleral; unsaturated dialdehydes; cytotoxicity;

D O I：

10.1016/j.bmc.2005.06.035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and in vitro cytotoxicity toward various tumor cell lines of (+/-)-tridemethylisovelleral, an analogue of the bioactive fungal sesquiterpene (+)-isovelleral retaining the bicyclo[4,1,0]hept-2-en-1,2-dicarbaidehyde system but lacking the three methyl groups, is reported. The cytotoxicity of tridemethylisovelleral toward several tumor cell lines was found to be comparable with those of established antitumor drugs, and significantly higher than that of isovelleral. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6145 / 6150

页数：6

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