Insulin resistance in latent autoimmune diabetes of adulthood

被引：24

作者：

Behme, MT

Dupré, J

Harris, SB

Hramiak, IM

Mahon, JL

机构：

[1] Univ Western Ontario, Lawson Hlth Res Inst, London, ON N6A 3K7, Canada

[2] Univ Western Ontario, Robarts Res Inst, London, ON N6A 3K7, Canada

[3] Univ Western Ontario, London Hlth Sci Ctr, London, ON N6A 3K7, Canada

来源：

IMMUNOLOGY OF DIABETES II: PATHOGENESIS FROM MOUSE TO MAN | 2003年 / 1005卷

关键词：

latent autoimmune diabetes of adulthood (LADA); homeostasis model assessment (HOMA); insulin resistance;

D O I：

10.1196/annals.1288.062

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance in patients with latent autoimmune diabetes of adulthood (LADA) was determined by homeostasis model assessment (HOMA). LADA was identified by a clinical phenotype of type 2 diabetes with antibodies to GAD65 and/or IA-2/ICA512. All patients were managed with insulin therapy. Insulin resistance in LADA was lower than in antibody-negative type 2 diabetes, higher than in normal humans and in recent-onset type I diabetes, and similar to that in long-term type 1 diabetes. Mean values for HOMA varied linearly with mean values for BMI, which accounted for much of the insulin resistance in these forms of diabetes. LADA resembles long-term type I diabetes with respect to insulin resistance and BMI, but occurs at an older age.

引用

页码：374 / 377

页数：4

共 7 条

[1]

Behme MT, 2002, DIABETES, V51, pA283

[2] A MODIFIED PROTOCOL FOR ESTIMATION OF INSULIN SENSITIVITY WITH THE MINIMAL MODEL OF GLUCOSE KINETICS IN PATIENTS WITH INSULIN-DEPENDENT DIABETES [J].