Bioadhesion and the dewetting transition

被引：54

作者：

Bruinsma, R

Sackmann, E

机构：

[1] Leids Inst Onderzoek Natuurkunde, Inst Lorentz Theoret Natuurkunde, NL-2333 CA Leiden, Netherlands

[2] Tech Univ Munich, Dept Phys, Biophys Lab E22, D-85747 Garching, Germany

来源：

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE IV PHYSIQUE ASTROPHYSIQUE | 2001年 / 2卷 / 06期

关键词：

biophysics; bioadhesion; ligand-receptor wetting; phase separation;

D O I：

10.1016/S1296-2147(01)01225-2

中图分类号：

P1 [天文学];

学科分类号：

0704 ;

摘要：

The article discusses interferometric experiments carried out on a number of receptor/ligand ('linker') based bioadhesion systems. The aim was to quantitatively test the applicability of wetting theory to bioadhesion. In all cases phase-separation phenomena were observed, with highly heterogeneous adhesion disks, which is not consistent with a simple equilibrium wetting description. We present both theoretical and experimental evidence that these phenomena can be best understood in terms of two concepts: (I) a membrane-mediated linker-linker attraction, and (II) a linker-controlled dewetting transition. (C) 2001 Academie des sciences/Editions scientifiques et medicales Elsevier SAS.

引用

页码：803 / 815

页数：13

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