Inhibitory effect of caffeic acid phenethyl ester on human leukemia HL-60 cells

被引：130

作者：

Chen, JH

Shao, Y

Huang, MT

Chin, CK

Ho, CT

机构：

[1] RUTGERS STATE UNIV,COOK COLL,NEW JERSEY AGR EXPT STN,DEPT FOOD SCI,NEW BRUNSWICK,NJ 08903

[2] RUTGERS STATE UNIV,COOK COLL,NEW JERSEY AGR EXPT STN,DEPT PLANT SCI,NEW BRUNSWICK,NJ 08903

[3] RUTGERS STATE UNIV,COLL PHARM,CANC RES LAB,DEPT BIOL CHEM,PISCATAWAY,NJ 08855

来源：

CANCER LETTERS | 1996年 / 108卷 / 02期

关键词：

caffeic acid phenethyl ester; HL-60; cells; antitumor; propolis; caffeic acid;

D O I：

10.1016/S0304-3835(96)04425-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Caffeic acid phenethyl ester (CAFE) was synthesized from caffeic acid and phenethyl alcohol (ratio 1:5) at room temperature with dicyclohexyl carbodiimide (DCC) as a condensing reagent. The yield was about 38%. CAFE was found to arrest the growth of human leukemia HL-60 cells. It also inhibits DNA, RNA and protein synthesis in HL-60 cells with IC50 of 1.0 mu M, 5.0 mu M and 1.5 mu M, respectively.

引用

页码：211 / 214

页数：4

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