Agouti-related peptide-expressing neurons are mandatory for feeding

被引：602

作者：

Gropp, E

Shanabrough, M

Borok, E

Xu, AW

Janoschek, R

Buch, T

Plum, L

Balthasar, N

Hampel, B

Waisman, A

Barsh, GS

Horvath, TL

Brüning, JC

机构：

[1] Univ Cologne, Inst Genet, D-50674 Cologne, Germany

[2] Univ Cologne, Ctr Mol Med CMMC, Dept Mouse Genet & Metab, D-50674 Cologne, Germany

[3] Yale Univ, Sch Med, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA

[4] Yale Univ, Sch Med, Dept Neurobiol, New Haven, CT 06520 USA

[5] Yale Univ, Sch Med, Comparat Med Sect, New Haven, CT 06520 USA

[6] Stanford Univ, Sch Med, Dept Genet & Pediat, Stanford, CA 94305 USA

[7] Univ Cologne, Dept Internal Med 2, D-50924 Cologne, Germany

[8] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Endocrinol, Boston, MA 02215 USA

[9] Johannes Gutenberg Univ Mainz, Med Klin & Poliklin 1, Unit Pathophysiol, D-55131 Mainz, Germany

来源：

NATURE NEUROSCIENCE | 2005年 / 8卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nn1548

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide ( AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.

引用

收藏

页码：1289 / 1291

页数：3

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