Insulin-like signaling, metabolism, stress resistance and aging in Caenorhabditis elegans

被引：89

作者：

Braeckman, BP ^{[1
]}

Houthoofd, K ^{[1
]}

Vanfleteren, JR ^{[1
]}

机构：

[1] Univ Ghent, Dept Biol, B-9000 Ghent, Belgium

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2001年 / 122卷 / 07期

关键词：

D O I：

10.1016/S0047-6374(01)00222-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

The nervous system acts as a major regulator of the life span of Caenorhabditis elegans. Temperature and chemical stimuli from the environment are integrated with internal signals from the reproductive system to specify adult longevity. An insulin-like signaling cascade acts in neurons and coordinates control of senescence of the entire organism by regulating metabolism and a stress response mechanism. Caloric restriction extends life span, possibly by activation of the stress response program. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：673 / 693

页数：21

共 93 条

[1]

Effects of oxygen on protein carbonyl and aging in Caenorhabditis elegans mutants with long (age-1) and short (mev-1) life spans [J].