Effect of cyclooxygenase-2 inhibitor (celecoxib) on the infarcted heart in situ

被引：8

作者：

Yamamoto, T ^{[1
]}

Kakar, NR ^{[1
]}

Vina, ER ^{[1
]}

Johnson, PE ^{[1
]}

Bing, RJ ^{[1
]}

机构：

[1] Huntington Med Res Inst, Dept Exptl Cardiol, Pasadena, CA 91101 USA

来源：

PHARMACOLOGY | 2001年 / 63卷 / 01期

关键词：

prostaglandin; nitric oxide; cyclooxygenase-2; aspirin; celecoxib; NCX-4016; myocardial infarction;

D O I：

10.1159/000056109

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Several attempts have been made to replace aspirin with compounds without gastric toxicity; a cyclooxygenase-2 (COX-2) inhibitor, celecoxib, and a nitric oxide-aspirin, NCX-4016, have been developed for this purpose, This paper compares effects of celecoxib, NCX-4016 and aspirin on production of prostacyclin (PGI(2)) and thromboxane A(2) (TXA(2)) and activation of the inducible form of nitric oxide synthase (INOS) in infarcted heart in situ. Aspirin was most effective in reducing myocardial PGI(2) synthesis and formation of TXA(2). Myocardial effects of celecoxib resemble those of NCX-4016, although the two compounds have different modes of action. Copyright (C) 2001 S.Karger AG, Basel.

引用

页码：28 / 33

页数：6

共 19 条

[1] Oxidation products of nitric oxide, NO2, and NO3, in plasma after experimental myocardial infarction [J].

Akiyama, K ;

Suzuki, H ;

Grant, P ;

Bing, RJ .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 1997, 29 (01) :1-9

[2] Production of oxidative products of nitric oxide in infarcted human heart [J].

Akiyama, K ;

Kimura, A ;

Suzuki, H ;

Takeyama, Y ;

Gluckman, TL ;

Terhakopian, A ;

Katagiri, T ;

Suh, KY ;

Roseto, J ;

Bing, RJ .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (02) :373-379

[3] GASTROINTESTINAL DAMAGE ASSOCIATED WITH THE USE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS [J].

ALLISON, MC ;

HOWATSON, AG ;

TORRANCE, CJ ;

LEE, FD ;

RUSSELL, RI .

NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (11) :749-754

[4] New look at myocardial infarction: toward a better aspirin [J].

Bing, RJ ;

Yamamoto, T ;

Yamamoto, M ;

Kakar, R ;

Cohen, A .

CARDIOVASCULAR RESEARCH, 1999, 43 (01) :25-31

[5] Myocardial infarction and nitric oxide [J].

Bing, RJ ;

Suzuki, H .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1996, 161 :303-306

[6] NITRIC-OXIDE MEDIATES GLUTAMATE-LINKED ENHANCEMENT OF CGMP LEVELS IN THE CEREBELLUM [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :9030-9033

[7] ASPIRIN INHIBITS THE EARLY MYOCARDIAL RELEASE OF THROMBOXANE-B2 AND VENTRICULAR ECTOPIC ACTIVITY FOLLOWING ACUTE CORONARY-ARTERY OCCLUSION IN DOGS [J].

COKER, SJ ;

LEDINGHAM, IM ;

PARRATT, JR ;

ZEITLIN, IJ .

BRITISH JOURNAL OF PHARMACOLOGY, 1981, 72 (04) :593-595

[8] INDUCIBLE NITRIC-OXIDE SYNTHASE ACTIVITY IN MYOCARDIUM AFTER MYOCARDIAL-INFARCTION IN RABBIT [J].

DUDEK, RR ;

WILDHIRT, S ;

CONFORTO, A ;

PINTO, V ;

SUZUKI, H ;

WINDER, S ;

BING, RJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1994, 205 (03) :1671-1680

[9] MACROPHAGE CYTOTOXICITY - ROLE FOR L-ARGININE DEIMINASE AND IMINO-NITROGEN OXIDATION TO NITRITE [J].

HIBBS, JB ;

TAINTOR, RR ;

VAVRIN, Z .

SCIENCE, 1987, 235 (4787) :473-476

[10] Aspirin-like molecules that covalently inactivate cyclooxygenase-2 [J].

Kalgutkar, AS ;

Crews, BC ;

Rowlinson, SW ;

Garner, C ;

Seibert, K ;

Marnett, LJ .

SCIENCE, 1998, 280 (5367) :1268-1270

← 1 2 →