The gut microbiota and its relationship to diet and obesity New insights

被引：370

作者：

Clarke, Siobhan F. ^{[1
,2
]}

Murphy, Eileen F. ^{[3
,4
]}

Nilaweera, Kanishka ^{[1
]}

Ross, Paul R. ^{[1
,3
]}

Shanahan, Fergus ^{[3
,5
]}

O'Toole, Paul W. ^{[2
,3
]}

Cotter, Paul D. ^{[1
,3
]}

机构：

[1] Teagasc Food Res Ctr, Moorepk, Fermoy, Cork, Ireland

[2] Univ Coll Cork, Microbiol Dept, Cork, Ireland

[3] Univ Coll Cork, Alimentary Pharmabiot Ctr, Cork, Ireland

[4] Alimentary Hlth Ltd, Cork, Ireland

[5] Univ Coll Cork, Dept Med, Cork, Ireland

来源：

GUT MICROBES | 2012年 / 3卷 / 03期

关键词：

gut microbiota; intervention; prebiotic; probiotic; diet and obesity; SERUM AMYLOID-A; INTESTINAL BACTERIAL OVERGROWTH; CONJUGATED LINOLEIC-ACID; ADIPOSE-TISSUE; WEIGHT-LOSS; INSULIN-RESISTANCE; ADIPONECTIN LEVELS; BODY-WEIGHT; INFLAMMATION; MICE;

D O I：

10.4161/gmic.20168

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Obesity develops from a prolonged imbalance of energy intake and energy expenditure. However, the relatively recent discovery that the composition and function of the gut microbiota impacts on obesity has lead to an explosion of interest in what is now a distinct research field. Here, research relating to the links between the gut microbiota, diet and obesity will be reviewed under five major headings: (1) the gut microbiota of lean and obese animals, (2) the composition of the gut microbiota of lean and obese humans, (3) the impact of diet on the gut microbiota, (4) manipulating the gut microbiota and (5) the mechanisms by which the gut microbiota can impact on weight gain.

引用

页码：186 / 202

页数：17

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