Ginsenoside Rh1 inhibits the invasion and migration of THP-1 acute monocytic leukemia cells via inactivation of the MAPK signaling pathway

被引：47

作者：

Choi, Yeo-Jin ^{[1
]}

Yoon, Ji-Hae ^{[1
]}

Cha, Seon-Woo ^{[2
]}

Lee, Seong-Gene ^{[1
]}

机构：

[1] Chonnam Natl Univ, Dept Biotechnol, Bioenergy Res Ctr, Kwangju 500757, South Korea

[2] RDA, Natl Inst Hort & Herbal Sci, Dept Herbal Crop Res, Eumseong 369873, South Korea

来源：

FITOTERAPIA | 2011年 / 82卷 / 06期

关键词：

Adhesion; Ginsenoside Rh1; Migration; Monocyte; Monocyte attractant protein-1; CCR2; MOLECULAR-MECHANISMS; PROTEIN-KINASE; CHEMOATTRACTANT; ACTIVATION; PROTOPANAXATRIOL; CHEMOTAXIS; RECEPTORS; INTEGRINS; DISEASE; MCP-1;

D O I：

10.1016/j.fitote.2011.05.005

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Ginsenoside Rh1 has been reported to possess antiallergic and anti-inflammatory activities, but its effects on monocytes remain to be determined. Herein, we investigated the effects of Rh1 on the expression of MCP-1 and CCR2, activation of MAPK signaling, and chemotaxis of monocytes. Treatment of Rh1 decreased the levels of MCP-1 and CCR2 and the expression of VLA5 and activated beta 1 integrin on the cell surface, and attenuated the phosphorylation of MAPKs. Based on these results, the inhibitory effects of Rh1 on monocyte function should be regarded as a promising new anti-inflammatory response with a potential therapeutic role against inflammation-dependent diseases. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：911 / 919

页数：9

共 30 条

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