Modulation of in vivo tumor radiation response via gold nanoshell-mediated vascular-focused hyperthermia: Characterizing an integrated antihypoxic and localized vascular disrupting targeting strategy

被引：171

作者：

Diagaradjane, Parmeswaran ^{[1
]}

Shetty, Anil ^{[2
]}

Wang, James C. ^{[1
,4
]}

Elliott, Andrew M. ^{[2
]}

Schwartz, Jon ^{[4
]}

Shentu, Shujun ^{[1
]}

Park, Hee C. ^{[1
]}

Deorukhkar, Amit ^{[1
]}

Stafford, R. Jason ^{[2
]}

Cho, Sang H. ^{[3
]}

Tunnell, James W. ^{[5
]}

Hazle, John D. ^{[2
]}

Krishnan, Sunil ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Expt Radiat Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Imaging Phys, Houston, TX 77030 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Phys, Houston, TX 77030 USA

[4] Nanospectra Biosci Inc, Houston, TX USA

[5] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 05期

关键词：

D O I：

10.1021/nl080496z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report noninvasive modulation of in vivo tumor radiation response using gold nanoshells. Mild-temperature hyperthermia generated by near-infrared illumination of gold nanoshell-laden tumors, noninvasively quantified by magnetic resonance temperature imaging, causes an early increase in tumor perfusion that reduces the hypoxic fraction of tumors. A subsequent radiation dose induces vascular disruption with extensive tumor necrosis. Gold nanoshells sequestered in the perivascular space mediate these two tumor vasculature-focused effects to improve radiation response of tumors. This novel integrated antihypoxic and localized vascular disrupting therapy can potentially be combined with other conventional antitumor therapies.

引用

页码：1492 / 1500

页数：9

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