Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

被引：34

作者：

Anastasina, Maria ^{[1
,4
]}

Le May, Nicolas ^{[2
]}

Bugai, Andrii ^{[3
]}

Fu, Yu ^{[1
]}

Soderholm, Sandra ^{[4
]}

Gaelings, Lana ^{[1
]}

Ohman, Tiina ^{[4
]}

Tynell, Janne ^{[5
]}

Kyttanen, Suvi ^{[1
]}

Barboric, Matjaz ^{[3
]}

Nyman, Tuula A. ^{[4
,6
]}

Matikainen, Sampsa ^{[3
]}

Julkunen, Ilkka ^{[5
,7
]}

Butcher, Sarah J. ^{[4
]}

Egly, Jean-Marc ^{[2
]}

Kainov, Denis E. ^{[1
]}

机构：

[1] Univ Helsinki, FIMM, FIN-00290 Helsinki, Finland

[2] IGBMC, Dept Funct Genom & Canc, F-67404 Strasbourg, France

[3] Univ Helsinki, Dept Biochem & Dev Biol, Medicum, FIN-00014 Helsinki, Finland

[4] Univ Helsinki, Inst Biotechnol, FIN-00014 Helsinki, Finland

[5] Natl Inst Hlth & Welf THL, Helsinki 00271, Finland

[6] Natl Hosp Norway, Inst Clin Med, Sognsvannsveien 20, N-0372 Oslo, Norway

[7] Univ Turku, Dept Virol, Turku 20014, Finland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 11期

基金：

芬兰科学院;

关键词：

Regulation of gene expression; Influenza A virus; Innate immunity; Antiviral responses; Viral counter-responses; DOUBLE-STRANDED-RNA; A VIRUS; INDUCIBLE GTPASES; STRUCTURAL BASIS; INFECTED-CELLS; INTERFERON; RECOGNITION; EXPRESSION; DOMAIN; SALIPHENYLHALAMIDE;

D O I：

10.1016/j.bbagrm.2016.09.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：1440 / 1448

页数：9

共 55 条

[1]

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice [J].