Order out of complexity - protein structures that interact with heparin

被引：137

作者：

Mulloy, B

Linhardt, RJ

机构：

[1] Natl Inst Biol Stand & Controls, Mol Struct Lab, Potters Bar EN6 3QG, Herts, England

[2] Univ Iowa, Dept Chem, Div Med Chem, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0959-440X(00)00257-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many proteins of widely differing functionality and structure are capable of binding heparin. Structural characterisations of the many types of such complexes are being reported in ever-increasing number and at improved resolution. Several crystal structures of complexes formed through the interaction of heparin-derived oligosaccharides with one or more protein partners have been described.

引用

收藏

页码：623 / 628

页数：6

相关论文

共 47 条

[1] The region of antithrombin interacting with full-length heparin chains outside the high-affinity pentasaccharide sequence extends to Lys136 but not to Lys139 [J].

Arocas, V ;

Turk, B ;

Bock, SC ;

Olson, ST ;

Björk, I .

BIOCHEMISTRY, 2000, 39 (29) :8512-8518

[2] The effect of a reducing-end extension on pentasaccharide binding by antithrombin [J].

Belzar, KJ ;

Dafforn, TR ;

Petitou, M ;

Carrell, RW ;

Huntington, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8733-8741

[3] Docking of glycosaminoglycans to heparin-binding proteins: Validation for aFGF, bFGF, and antithrombin and application to IL-8 [J].

Bitomsky, W ;

Wade, RC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (13) :3004-3013

[4] Annexin V-heparin oligosaccharide complex suggests heparan sulfate-mediated assembly on cell surfaces [J].

Capila, I ;

Hernaiz, MJ ;

Mo, YD ;

Mealy, TR ;

Campos, B ;

Dedman, JR ;

Linhardt, RJ ;

Seaton, BA .

STRUCTURE, 2001, 9 (01) :57-64

[5]

CAPILA I, 2001, IN PRESS ANGEW CHEM

[6] Structure of a heparin-linked biologically active dimer of fibroblast growth factor [J].

DiGabriele, AD ;

Lax, I ;

Chen, DI ;

Svahn, CM ;

Jaye, M ;

Schlessinger, J ;

Hendrickson, WA .

NATURE, 1998, 393 (6687) :812-817

[7]

DRUMMOND KJ, 2001, ELECTROPHORESIS, V22, P304

[8] Diversity does make a difference: fibroblast growth factor-heparin interactions [J].

Faham, S ;

Linhardt, RJ ;

Rees, DC .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1998, 8 (05) :578-586

[9] Heparin structure and interactions with basic fibroblast growth factor [J].

Faham, S ;

Hileman, RE ;

Fromm, JR ;

Linhardt, RJ ;

Rees, DC .

SCIENCE, 1996, 271 (5252) :1116-1120

[10] Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma [J].

Fath, MA ;

Wu, XJ ;

Hileman, RE ;

Linhardt, RJ ;

Kashem, MA ;

Nelson, RM ;

Wright, CD ;

Abraham, WM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (22) :13563-13569

← 1 2 3 4 5 →