An introduction to induced pluripotent stem cells

被引：21

作者：

Hanley, Joanna ^{[1
]}

Rastegarlari, Ghasem ^{[1
]}

Nathwani, Amit C. ^{[1
,2
]}

机构：

[1] UCL, Inst Canc, Dept Haematol, London WC1E 6BT, England

[2] NHS Blood & Transplant, London, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 151卷 / 01期

基金：

英国医学研究理事会;

关键词：

Embryonic stem cells; HUMAN FIBROBLASTS; SOMATIC-CELLS; GENE-THERAPY; GENERATION; INDUCTION; MOUSE; LINES; TRANSPLANTATION; DERIVATION; FUSION;

D O I：

10.1111/j.1365-2141.2010.08296.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

P>Recent landmark studies show that it is now possible to convert somatic cells, such as skin fibroblasts and B lymphocytes, into pluripotent stem cells that closely resemble embryonic stem cells. These induced pluripotent stem (iPS) cells can be generated without using human embryos or oocytes, thus bypassing some of the ethical issues that have limited the use of human embryonic stems (hES) cells. Additionally, they can be derived from the patient to be treated, thereby overcoming problems of immunological rejection associated with the use of allogeneic hES cell derived progenitors. Whilst these patient-specific iPS cells have great clinical potential, their immediate utility is likely to be in drug screening and for understanding the disease process. This review discusses the promise of iPS cells as well as the challenges to their use in the clinic.

引用

页码：16 / 24

页数：9

共 61 条

[1] Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes [J].

Aasen, Trond ;

Raya, Angel ;

Barrero, Maria J. ;

Garreta, Elena ;

Consiglio, Antonella ;

Gonzalez, Federico ;

Vassena, Rita ;

Bilic, Josipa ;

Pekarik, Vladimir ;

Tiscornia, Gustavo ;

Edel, Michael ;

Boue, Stephanie ;

Izpisua Belmonte, Juan Carlos .

NATURE BIOTECHNOLOGY, 2008, 26 (11) :1276-1284

[2] Characterization of human embryonic stem cell lines by the International Stem Cell Initiative [J].

Adewumi, Oluseun ;

Aflatoonian, Behrouz ;

Ahrlund-Richter, Lars ;

Amit, Michal ;

Andrews, Peter W. ;

Beighton, Gemma ;

Bello, Paul A. ;

Benvenisty, Nissim ;

Berry, Lorraine S. ;

Bevan, Simon ;

Blum, Barak ;

Brooking, Justin ;

Chen, Kevin G. ;

Choo, Andre B. H. ;

Churchill, Gary A. ;

Corbel, Marie ;

Damjanov, Ivan ;

Draper, Jon S. ;

Dvorak, Petr ;

Emanuelsson, Katarina ;

Fleck, Roland A. ;

Ford, Angela ;

Gertow, Karin ;

Gertsenstein, Marina ;

Gokhale, Paul J. ;

Hamilton, Rebecca S. ;

Hampl, Ales ;

Healy, Lyn E. ;

Hovatta, Outi ;

Hyllner, Johan ;

Imreh, Marta P. ;

Itskovitz-Eldor, Joseph ;

Jackson, Jamie ;

Johnson, Jacqueline L. ;

Jones, Mark ;

Kee, Kehkooi ;

King, Benjamin L. ;

Knowles, Barbara B. ;

Lako, Majlinda ;

Lebrin, Franck ;

Mallon, Barbara S. ;

Manning, Daisy ;

Mayshar, Yoav ;

Mckay, Ronald D. G. ;

Michalska, Anna E. ;

Mikkola, Milla ;

Mileikovsky, Masha ;

Minger, Stephen L. ;

Moore, Harry D. ;

Mummery, Christine L. .

NATURE BIOTECHNOLOGY, 2007, 25 (07) :803-816

[3] Generation of pluripotent stem cells from adult mouse liver and stomach cells [J].

Aoi, Takashi ;

Yae, Kojiro ;

Nakagawa, Masato ;

Ichisaka, Tomoko ;

Okita, Keisuke ;

Takahashi, Kazutoshi ;

Chiba, Tsutomu ;

Yamanaka, Shinya .

SCIENCE, 2008, 321 (5889) :699-702

[4] Protective Effects of Human iPS-Derived Retinal Pigment Epithelium Cell Transplantation in the Retinal Dystrophic Rat [J].

Carr, Amanda-Jayne ;

Vugler, Anthony A. ;

Hikita, Sherry T. ;

Lawrence, Jean M. ;

Gias, Carlos ;

Chen, Li Li ;

Buchholz, David E. ;

Ahmado, Ahmad ;

Semo, Ma'ayan ;

Smart, Matthew J. K. ;

Hasan, Shazeen ;

da Cruz, Lyndon ;

Johnson, Lincoln V. ;

Clegg, Dennis O. ;

Coffey, Pete J. .

PLOS ONE, 2009, 4 (12)

[5]

Carr AJ, 2009, MOL VIS, V15, P283

[6]

CAVALERI F, 2010, STEM CELL ANTHOLOGY, P119

[7] Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells [J].

Cowan, CA ;

Atienza, J ;

Melton, DA ;

Eggan, K .

SCIENCE, 2005, 309 (5739) :1369-1373

[8]

Cowan CA, 2004, NEW ENGL J MED, V350, P1353, DOI 10.1056/NEJMsr040330

[9] Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons [J].

Dimos, John T. ;

Rodolfa, Kit T. ;

Niakan, Kathy K. ;

Weisenthal, Laurin M. ;

Mitsumoto, Hiroshi ;

Chung, Wendy ;

Croft, Gist F. ;

Saphier, Genevieve ;

Leibel, Rudy ;

Goland, Robin ;

Wichterle, Hynek ;

Henderson, Christopher E. ;

Eggan, Kevin .

SCIENCE, 2008, 321 (5893) :1218-1221

[10] Reprogramming somatic gene activity by fusion with pluripotent cells [J].

Do, Jeong Tae ;

Han, Dong Wook ;

Schoeler, Hans R. .

STEM CELL REVIEWS, 2006, 2 (04) :257-264

← 1 2 3 4 5 6 7 →