Amniotic membrane transplantation in acute chemical burns

被引:73
作者
Arora, R [1 ]
Mehta, D [1 ]
Jain, V [1 ]
机构
[1] Guru Nanak Eye Ctr, Cornea Serv, New Delhi 110002, India
关键词
amniotic membrane transplantation; chemical burns; limbal stem cell deficiency; persistent epithelial defect; limbal stem cell transplantation;
D O I
10.1038/sj.eye.6701490
中图分类号
R77 [眼科学];
学科分类号
100212 [眼科学];
摘要
Purpose To evaluate the outcome of fresh amniotic membrane transplantation (AMT) for ocular surface reconstruction in acute chemical burns. Methods A prospective study of 15 consecutive eyes with acute chemical burns was performed. In all, 10 eyes had lime burns and five eyes had acid burns. There were three eyes of grade II, four eyes of grade III and eight eyes of grade IV burns. AMT was performed within 3 weeks of injury. Results Patients were followed up for 10.14+/-4.41 months. All patients had immediate relief of pain postoperatively. Of 15 eyes, nine (60%) showed epithelialization within 1-4 weeks (15.33+/-9.91 days). The final visual acuity improved in 10 of 15 eyes (66.66%). Eyes with burns of grade II and III showed more visual improvement than those with grade IV burns. None of the eyes showed perforation. Symblepharon was seen in nine of 15 eyes (60%). Of 15 eyes, 12 (80%) experienced limbal stem cell deficiency and showed superficial corneal vascularization. Conclusions Amniotic membrane transplantation with fresh amniotic membrane increases patient comfort and reduces inflammation. In mild burns, AMT alone restores corneal and conjunctival surfaces. In moderate to severe burns, it probably reduces conjunctival scarring sequelae, but does not prevent the sequelae of limbal stem cell deficiency that requires further limbal stem cell transplantation. In the acute stage, amniotic membrane transplantation probably has a protective role against the progressive melting and perforation.
引用
收藏
页码:273 / 278
页数:6
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