Changes in the responses of Purkinje cells in the floccular complex of monkeys after motor learning in smooth pursuit eye movements

被引:57
作者
Kahlon, M
Lisberger, SG
机构
[1] Univ Calif San Francisco, Dept Physiol, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Grad Program Neurosci, San Francisco, CA 94143 USA
[4] Univ Calif San Francisco, WM Keck Fdn, Ctr Integrat Neurosci, San Francisco, CA 94143 USA
关键词
D O I
10.1152/jn.2000.84.6.2945
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
We followed simple- and complex-spike firing of Purkinje cells (PCs) in the floccular complex of the cerebellum through learned modifications of the pursuit eye movements of two monkeys. Learning was induced by double steps of target speed in which initially stationary targets move at a "learning" speed for 100 ms and then change to either a higher or lower speed in the same direction. In randomly interleaved control trials, targets moved at the learning speed in the opposite direction. When the learning direction was the ON direction for simple- spike responses, learning was associated with statistically significant changes in simple- spike firing for 10 of 32 PCs. Of the 10 PCs that showed significant expressions of learning, 8 showed changes in simple-spike output in the expected direction: increased or decreased firing when eye acceleration increased or decreased through learning. There were no statistically significant changes in simple- spike responses or eye acceleration during pursuit in the control direction. When the learning direction was in the OFF direction for simple- spike responses, none of 15 PCs showed significant correlates of learning. Although changes in simple-spike firing were recorded in only a subset of PCs, analysis of the population response showed that the same relationship between population firing and eye acceleration obtained before and after learning. Thus learning is associated with changes that render the modified population response appropriate to drive the changed behavior. To analyze complex-spike firing during learning we correlated complex-spike firing in the second, third, and fourth 100 ms after the onset of target motion with the retinal image motion in the previous 100 ms. Data were largely consistent with previous evidence that image motion drives complex spikes with a direction selectivity opposite that for simple spikes. Comparison of complex-spike responses at different times after the onset of control and learning target motions in the learning direction implied that complex spikes could guide learning during decreases but not increases in eye acceleration. Learning caused increases or decreases in the sensitivity of complex spikes to image motion in parallel with changes in eye acceleration. Complex-spike responses were similar in all PCs, including many in which learning did not modify simple- spike responses. Our data do not disprove current theories of cerebellar learning but suggest that these theories would have to be modified to account for simple- and complex-spike firing of floccular Purkinje cells reported here.
引用
收藏
页码:2945 / 2960
页数:16
相关论文
共 57 条
[1]  
ALBUS J S, 1971, Mathematical Biosciences, V10, P25, DOI 10.1016/0025-5564(71)90051-4
[2]   SUBCORTICAL CONNECTIONS OF VISUAL AREAS MST AND FST IN MACAQUES [J].
BOUSSAOUD, D ;
DESIMONE, R ;
UNGERLEIDER, LG .
VISUAL NEUROSCIENCE, 1992, 9 (3-4) :291-302
[4]  
BRODAL P, 1979, NEUROSCIENCE, V4, P193, DOI 10.1016/0306-4522(79)90082-4
[5]   DIRECTIONAL PURSUIT DEFICITS FOLLOWING LESIONS OF THE FOVEAL REPRESENTATION WITHIN THE SUPERIOR TEMPORAL SULCUS OF THE MACAQUE MONKEY [J].
DURSTELER, MR ;
WURTZ, RH ;
NEWSOME, WT .
JOURNAL OF NEUROPHYSIOLOGY, 1987, 57 (05) :1262-1287
[6]   PURSUIT AND OPTOKINETIC DEFICITS FOLLOWING CHEMICAL LESIONS OF CORTICAL AREAS MT AND MST [J].
DURSTELER, MR ;
WURTZ, RH .
JOURNAL OF NEUROPHYSIOLOGY, 1988, 60 (03) :940-965
[7]   Neuronal responses in visual areas MT and MST during smooth pursuit target selection [J].
Ferrera, VP ;
Lisberger, SG .
JOURNAL OF NEUROPHYSIOLOGY, 1997, 78 (03) :1433-1446
[8]   PARTICIPATION OF THE CAUDAL FASTIGIAL NUCLEUS IN SMOOTH-PURSUIT EYE-MOVEMENTS .1. NEURONAL-ACTIVITY [J].
FUCHS, AF ;
ROBINSON, FR ;
STRAUBE, A .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (06) :2714-2728
[9]  
Fukushima K, 1996, NEUROSCI RES, V25, P391
[10]   CLIMBING FIBER RESPONSES OF PURKINJE-CELLS TO RETINAL IMAGE MOVEMENT IN CAT CEREBELLAR FLOCCULUS [J].
FUSHIKI, H ;
SATO, Y ;
MIURA, A ;
KAWASAKI, T .
JOURNAL OF NEUROPHYSIOLOGY, 1994, 71 (04) :1336-1350