Primary tert- and sec-allylamines via palladium-catalyzed hydroamination and allylic substitution with hydrazine and hydroxylamine derivatives

被引：107

作者：

Johns, Adam M.

Liu, Zhijian

Hartwig, John F.

机构：

[1] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

[2] Yale Univ, Dept Chem, New Haven, CT 06520 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 38期

关键词：

allylic substitution; homogeneous catalysis; hydroamination; palladium;

D O I：

10.1002/anie.200701899

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Amines of control: Palladium-catalyzed reactions of hydrazine and hydroxylamine derivatives with dienes and allylic esters form products from C-N bond formation at the more substituted position of the allyl intermediate with a broad range of ligands on palladium (see scheme; X=NCPh2 or OR; Ac = acetyl). These reactions provide a route to highly substituted primary amines by facile cleavage of the N-O and N-N bonds. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：7259 / 7261

页数：3

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