Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity

被引：726

作者：

Shimomura, I

Funahashi, T

Takahashi, M

Maeda, K

Kotani, K

Nakamura, T

Yamashita, S

Miura, M

Fukuda, Y

Takemura, K

Tokunaga, K

Matsuzawa, Y

机构：

[1] OSAKA UNIV,SCH MED,DEPT INTERNAL MED 2,SUITA,OSAKA 565,JAPAN

[2] MITSUBISHI KAGAKU BIOCLIN LABS,ITABASHI KU,TOKYO 174,JAPAN

[3] OTSUKA ASSAY LABS,HIRAI,TOKUSHIMA,JAPAN

来源：

NATURE MEDICINE | 1996年 / 2卷 / 07期

关键词：

D O I：

10.1038/nm0796-800

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The presence of obesity increases the risk of thrombotic vascular diseases. The role of fat accumulation and its effect on plasminogen activator inhibitor-1 (PAI-1) levels was investigated in humans and animals. Plasma PAI-1 levels were closely correlated with visceral fat area but not with subcutaneous fat area in human subjects. PAI-1 mRNA was detected in both types of fat tissue in obese rats but increased only in visceral fat during the development of obesity. These data suggest that an enhanced expression of the PAI-7 gene in visceral fat may increase plasma levels and may have a role in the development of vascular disease in visceral obesity.

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收藏

页码：800 / 803

页数：4

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