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3,4-Dichloroaniline-induced oxidative stress in liver of crucian carp (Carassius auratus)

被引：52
作者：
Li, WM
Yin, DQ
Zhou, Y
Hu, SQ
Wang, LS
机构：
[1] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210093, Peoples R China
[2] Environm Monitoring Stn Nanyang, Nanyang 473000, Peoples R China
来源：
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2003年 / 56卷 / 02期
关键词：
3,4-dichloroaniline; superoxide dismutase; malondialdehyde; glutathione; oxidative stress; lipid peroxiclation; nitric oxide; nitric oxide synthase; LIPID-PEROXIDATION; ALPHA-TOCOPHEROL; NITRIC-OXIDE; TOXICITY; MECHANISMS; ANTIOXIDANTS; XENOBIOTICS; CHEMICALS; DISMUTASE; MUSCLE;
D O I：
10.1016/S0147-6513(02)00117-3
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
3,4-Dichloroaniline (DCA) and its analogs are widely used as chemical intermediates in the synthesis of herbicides, azo dyes, and pharmaceuticals. They bring danger to growth, development, and propagation of aquatic organisms. The purpose of this study was to show DCA-induced oxidative stress response in liver of crucian carp (Carassius auratus). Superoxide dismutase (SOD), malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO), and NO synthase (NOS) in liver were measured in crucian carp after exposure to DCA solution (0.2, 0.4, and 0.8 mg/L, respectively) for 15 days and compared with the control. DCA significantly induced SOD activity and enhanced MDA concentration in liver of crucian carp. Compared with the control, GSH and NO concentrations decreased and NOS activity was inhibited in crucian carp liver 15 days after DCA treatment. The data suggested that DCA-induced free radical generation and antioxidant depletion, and caused oxidative stress and lipid peroxidation in liver of crucian carp. (C) 2003 Elsevier Science (USA). All rights reserved.
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收藏
页码：251 / 255
页数：5
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