Antibodies to west nile virus: A double-edged sword

被引:14
作者
Klasse, Per Johan
Burton, Dennis R.
机构
[1] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA
[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1016/j.chom.2007.04.001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Antibodies, although critical for host defense against West Nile virus (WNV), can both neutralize and enhance viral infection. In this issue of Cell Host & Microbe, Pierson et al. dissect these opposing effects and demonstrate that, when 120 epitopes are available per WNV virion, similar to 25 are occupied by antibody at 50% neutralization. At lower occupancies, enhancement of infection dominates; at higher ones, neutralization ensues. These results are important for WNV vaccine design and for potential therapeutic use of antibodies to WNV.
引用
收藏
页码:87 / 89
页数:3
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