A C-glycosidation approach to the central core of amphidinol 3:: Synthesis of the C39-C52 fragment

被引：44

作者：

de Vicente, J ^{[1
]}

Betzemeier, B ^{[1
]}

Rychnovsky, SD ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 09期

关键词：

D O I：

10.1021/ol050477l

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise route to an advance precursor (3) of the central core of amphidinol 3, a natural occurring polyketide, has been developed by applying a reductive lithiation as key step. The origin of the diastereoselectivity of this reaction was comprehensively studied for nucleophilic C-glycoside donor 5 and differently protected analogues.

引用

页码：1853 / 1856

页数：4

共 25 条

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