Metabolic aspects of the extreme longevity

被引：29

作者：

Barbieri, M. ^{[1
]}

Gambardella, A. ^{[1
]}

Paolisso, G. ^{[1
]}

Varricchio, M. ^{[1
]}

机构：

[1] Univ Naples 2, Dept Geriatr Med & Metab Dis, I-80138 Naples, Italy

来源：

EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 02期

关键词：

aging; human longevity; insulin resistance; anthropometric changes;

D O I：

10.1016/j.exger.2007.06.003

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Starting from young to very old subjects, aging is associated with a progressive remodeling. Such an age-dependent remodeling process mainly affects anthropometrics, endocrine and thus, also metabolic factors. Interestingly, it occurs in some individuals successfully, while in others unsuccessfully. Centenarians in good health conditions are a very selected group of subjects representing an exceptional condition. Why the centenarians reach the extreme human life span is still unknown. Thus, in this article we will review the best known causes of age-related insulin resistance, outline the main metabolic differences between aged subjects and healthy centenarians, underline the clinical relevance of insulin resistance in the elderly and finally, we will try to propose a unifying hypothesis for explaining the development of insulin resistance with aging. (c) 2008 Published by Elsevier Inc.

引用

页码：74 / 78

页数：5

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