In vivo anti-inflammatory effect of a new steroidal saponin, mannioside A, and its derivatives isolated from Dracaena mannii

被引：50

作者：

Azefack Tapondjou, Leon ^{[2
]}

Beaudelaire Ponou, Kemvoufo ^{[2
]}

Bertrand Teponno, Remy ^{[2
]}

Mbiantcha, Marius ^{[3
]}

Desire Djoukeng, Jules ^{[2
,4
]}

Nguelefack, Telesphore Benoit ^{[3
]}

Watcho, Pierre ^{[3
]}

Gomez Cadenas, Aurelio ^{[4
]}

Park, Hee-Juhn ^{[1
]}

机构：

[1] Sangji Univ, Div Appl Plant Sci, Dept Pharmaceut Engn, Wonju 220702, South Korea

[2] Univ Dschang, Fac Sci, Dept Chem, Dschang, Cameroon

[3] Univ Dschang, Fac Sci, Dept Anim Biol, Dschang, Cameroon

[4] Univ Jaume, Escola Super Technol Ciencies Expt, Dept Ciencies Agr Med Nat, Castellon de La Plana, Spain

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2008年 / 31卷 / 05期

关键词：

Dracaena mannii; mannioside A; steroid saponin; anti-inflammatory;

D O I：

10.1007/s12272-001-1208-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A new steroidal saponin, mannioside A (1), was isolated from the stem bark of Dracaena mannii, together with the known pennogenin (2), pennogenin-3-O-beta-D-glucopyranoside (3) and pennogenin-3-O-alpha-L-rhamnopyranosyl-(1 -> 2)-[alpha-L-rhamnopyranosyl-(1 -> 3)]-beta-D-glucopyranoside (4). Their structures were determined using 1D-and 2D-NMR spectroscopy and mass spectrometry. Compounds 1 and 3 significantly inhibited carrageenan-induced paw edema in the rat; compound 4 was moderately active whereas 2 showed very weak activity.

引用

页码：653 / 658

页数：6

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