QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) Using Venular-Targeted Velocity-Selective Spin Labeling

被引:127
作者
Bolar, D. S. [1 ,2 ,3 ]
Rosen, B. R. [2 ,3 ]
Sorensen, A. G. [2 ,3 ]
Adalsteinsson, E. [1 ,2 ,3 ]
机构
[1] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[2] Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA USA
[3] Harvard Univ, MIT, Harvard Mit Div Hlth Sci & Technol, Sch Med, Cambridge, MA 02139 USA
关键词
cerebral metabolic rate of oxygen; arterial spin labeling; velocity selective; oxygen extraction fraction; CEREBRAL METABOLIC-RATE; IN-VIVO MEASUREMENT; BLOOD-VOLUME; RELAXATION-TIME; BRAIN; MRI; QUANTIFICATION; FLOW; PET; VALIDATION;
D O I
10.1002/mrm.22946
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
While oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO(2)) are fundamental parameters of brain health and function, a robust MRI-based mapping of OEF and CMRO(2) amenable to functional MRI (fMRI) has not been established. To address this issue, a novel method called QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption, or QUIXOTIC, is introduced. The key innovation in QUIXOTIC is the use of velocity-selective spin labeling to isolate MR signal exclusively from postcapillary venular blood on a voxel-by-voxel basis. Measuring the T(2) of this venular-targeted blood allows calibration to venular oxygen saturation (Y(v)) via theoretical and experimental T(2) versus blood oxygen saturation relationships. Y(v) is converted to OEF, and baseline CMRO(2) is subsequently estimated from OEF and additional cerebral blood flow and hematocrit measurements. Theory behind the QUIXOTIC technique is presented, and implications of cutoff velocity (V(CUTOFF)) and outflow time parameters are discussed. Cortical gray matter values obtained with QUIXOTIC in 10 healthy volunteers are Y(v) = 0.73 +/- 0.02, OEF 5 0.26 +/- 0.02, and CMRO(2) = 125 +/- 15 mu mol/100 g min. Results are compared to global measures obtained with the T(2) relaxation under spin tagging (TRUST) technique. The preliminary data presented suggest that QUIXOTIC will be useful for mapping Y(v), OEF, and CMRO(2), in both clinical and functional MRI settings. Magn Reson Med 66:1550-1562, 2011. (C) 2011 Wiley Periodicals, Inc.
引用
收藏
页码:1550 / 1562
页数:13
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