Linking neurodevelopmental and synaptic theories of mental illness through DISC1

被引：322

作者：

Brandon, Nicholas J. ^{[1
]}

Sawa, Akira ^{[2
,3
]}

机构：

[1] Pfizer Neurosci, Groton, CT 06437 USA

[2] Johns Hopkins Univ, Dept Psychiat & Behav Neurosci, Sch Med, Baltimore, MD 21287 USA

[3] Johns Hopkins Univ, Dept Neurosci, Sch Med, Baltimore, MD 21287 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 12期

关键词：

IN-SCHIZOPHRENIA; 1; GENOME-WIDE ASSOCIATION; NEWLY GENERATED NEURONS; UTERO GENE-TRANSFER; DISRUPTED-IN-SCHIZOPHRENIA-1; DISC1; GRAY-MATTER; SCHIZOAFFECTIVE DISORDER; PROGENITOR PROLIFERATION; BEHAVIORAL PHENOTYPES; HIPPOCAMPAL-FORMATION;

D O I：

10.1038/nrn3120

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent advances in our understanding of the underlying genetic architecture of psychiatric disorders has blown away the diagnostic boundaries that are defined by currently used diagnostic manuals. The disrupted in schizophrenia 1 (DISC1) gene was originally discovered at the breakpoint of an inherited chromosomal translocation, which segregates with major mental illnesses. In addition, many biological studies have indicated a role for DISC1 in early neurodevelopment and synaptic regulation. Given that DISC1 is thought to drive a range of endophenotypes that underlie major mental conditions, elucidating the biology of DISC1 may enable the construction of new diagnostic categories for mental illnesses with a more meaningful biological foundation.

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收藏

页码：707 / 722

页数：16

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