Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling

被引：4

作者：

Cimponeriu, A ^{[1
]}

Starmer, CF ^{[1
]}

Bezerianos, A ^{[1
]}

机构：

[1] Univ Patras, Sch Med, Dept Phys Med, Rion Patras 26500, Greece

来源：

COMPUTERS IN CARDIOLOGY 1998, VOL 25 | 1998年 / 25卷

关键词：

D O I：

10.1109/CIC.1998.731797

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to identify generic mechanisms for altering the ECG during ischemia, we explored changes in the action potential propagation during different ischemic conditions using simple cellular models. Based on the Beeler-Reuter and Lou-Rudy I cellular models, we developed a ventricular tissue model for probing how alterations in shape and propagation of action potential distorted the theoretical ECG signal. If arrhythmias are a characteristic of acute ischemia, the changes in ST segment duration and T wave shape seems to be related with chronic ischemia and presence of the unexcitable medium. During different stages of ischemia, the changes in theoretical ECG indicated possibilities for detecting the relation between cellular changes and external measurement of the electrical activity of the heart.

引用

页码：317 / 320

页数：4