Complement and renal transplantation: From donor to recipient

被引：57

作者：

Damman, Jeffrey ^{[1
]}

Schuurs, Theo A. ^{[1
]}

Ploeg, Rutger J. ^{[1
]}

Seelen, Marc A. ^{[2
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Dept Surg, CMC V,Y2144, NL-9713 GZ Groningen, Netherlands

[2] Univ Med Ctr Groningen, Dept Nephrol, Groningen, Netherlands

来源：

TRANSPLANTATION | 2008年 / 85卷 / 07期

关键词：

brain death; donor; complement; kidney;

D O I：

10.1097/TP.0b013e3181683cf5

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Long-term kidney graft survival is affected by different variables including donor condition, ischemia-reperfusion injury, and graft rejection during the transplantation process. The complement system is an important mediator of renal ischemia-reperfusion injury and in rejecting allografts. However, donor complement C3 seems to be crucial in renal transplantation-related injury as renal injury is attenuated in C3 deficient kidney grafts. Interestingly, before ischemia-reperfusion induced C3 expression, C3 is already induced in donors suffering from brain death. Therefore, strategies targeting complement activation in the brain-dead donor may increase graft viability and transplant outcome.

引用

收藏

页码：923 / 927

页数：5

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