Enantiomeric separation of some clinically used racemic drugs on Pirkle-1J chiral stationary phase

被引：7

作者：

Chilmonczyk, Z

Ksycinska, H

Aboul-Enein, HY

Lee, WJ

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Biol & Med Res Dept MBC 03, Pharmaceut Anal Lab, Riyadh 11211, Saudi Arabia

[2] Drug Inst, PL-00725 Warsaw, Poland

[3] Univ Bialystok, Inst Chem, PL-15443 Bialystok, Poland

[4] Pharmaceut Res Inst, PL-01793 Warsaw, Poland

[5] Chosun Univ, Coll Pharm, Kwangju 501759, South Korea

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2001年 / 24卷 / 16期

关键词：

D O I：

10.1081/JLC-100105956

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The enantiomeric. separation of several clinically used racemic drugs has been achieved on N-(3,5-dinitrobenzoyl)-3-amino-4phenylazetidin-2-one bound to silica chiral stationary phase known as Pirkle-1J The chiral recognition mechanisms involved between the analytes and chiral stationary phase were explained using molecular modelling semi-empirical AM1 method. The results indicate that this phase is successful in resolution of beta -adrenergic blockers.

引用

页码：2505 / 2512

页数：8

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