The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations

被引：42

作者：

Portman, AT

Giladi, N

Leenders, KL

Maguire, P

Veenma-van der Duin, L

Swart, J

Pruim, J

Simon, ES

Hassin-Baer, S

Korczyn, AD

机构：

[1] Univ Groningen Hosp, Movement Disorder Unit, Dept Neurol, NL-9700 RB Groningen, Netherlands

[2] Tel Aviv Univ, Sackler Sch Med, Tel Aviv Sourasky Med Ctr, Dept Neurol,Movment Disorder Unit, IL-69978 Tel Aviv, Israel

[3] Univ Groningen Hosp, PET Ctr, Groningen, Netherlands

[4] Tel Aviv Univ, Sch Med, Sieratzki Chair Neurol, Ramat Aviv, Israel

来源：

NEUROLOGY | 2001年 / 56卷 / 12期

关键词：

D O I：

10.1212/WNL.56.12.1759

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.

引用

页码：1759 / 1762

页数：4

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