Sensitive NMR sensors detect antibodies to influenza

被引：67

作者：

Koh, Isaac ^{[1
,2
]}

Hong, Rid ^{[1
,2
]}

Weissleder, Ralph ^{[1
,2
]}

Josephson, Lee ^{[1
,2
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Mol Imaging Res, Boston, MA 02129 USA

[2] Harvard Univ, Sch Med, Boston, MA 02129 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 22期

关键词：

antibodies; biosensors; magnetic properties; peptides; viruses;

D O I：

10.1002/anie.200800069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Catching the flu: Magnetic particle aggregation has been used to provide a highly sensitive, NMR-based sensor for detecting antibodies to an influenza virus. To achieve high sensitivity, a homogeneous magnetic field (H) was employed to enhance antibody-based cross-linking between particles suspended in solution (see scheme; ΔT2: change in the transverse relaxation time). © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4119 / 4121

页数：3

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