Lutropin receptor function: Insights from natural, engineered, and computer-simulated mutations

被引：17

作者：

Fanelli, F

Themmen, APN

Puett, D

机构：

[1] Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA

[2] Univ Modena, Dept Chem, I-41100 Modena, Italy

[3] Erasmus Univ, Dept Endocrinol & Reprod, NL-3000 DR Rotterdam, Netherlands

来源：

IUBMB LIFE | 2001年 / 51卷 / 03期

关键词：

G protein-coupled receptor; gonadotropin; molecular modeling; mutagenesis;

D O I：

10.1080/152165401753544214

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The lutropin receptor is a member of the superfamily of G protein-coupled receptors and, in humans, binds two closely related ligands, members of the heterodimer glycoprotein hormone family. As reviewed herein, comparative analyses of natural, engineered, and computer-simulated mutations of the lutropin receptor have provided considerable insight into the molecular basis of receptor function.

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收藏

页码：149 / 155

页数：7

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