Structural diversification of taxanes by whole-cell biotransformation

被引：30

作者：

Dai, Jungui ^{[1
,2
,3
]}

Qu, Runjiang ^{[1
]}

Zou, Jian-hua ^{[2
,3
]}

Chen, Xiaoguang ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, Beijing 100050, Peoples R China

[2] Minist Publ Hlth, Key Lab Biosynth Nat Prod, Peking Union Med Coll, Beijing 100050, Peoples R China

[3] Minist Educ, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

来源：

TETRAHEDRON | 2008年 / 64卷 / 35期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

structural diversification; taxanes; whole-cell biotransformation;

D O I：

10.1016/j.tet.2008.06.062

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

The structural diversification of four 4(20),11(12)-taxadienes (sinenxan A and its two derivatives, and yunanxane) by microbial/plant whole-cell enzymatic transformation has been achieved; 53 derivatives have been obtained, and 41 of them are new compounds. The occurred reactions exhibited diversity, including hydroxylation, epoxidation, oxidation, hydrolysis, acylation, O-alkylation, O-glycosylation, rearrangement, etc. In addition, one chemical derivative, 9 alpha-cinnamoyl sinenxan A from one enzymatic product 9 alpha-hydroxyl sinenxan A, displayed significant reversal activity toward three MDR tumor cell lines (A549/taxol, KB/VCR, and HCT-8). (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：8102 / 8116

页数：15

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