Protection against myxomatosis and rabbit viral hemorrhagic disease with recombinant myxoma viruses expressing rabbit hemorrhagic disease virus capsid protein

被引：63

作者：

Bertagnoli, S

Gelfi, J

LeGall, G

Boilletot, E

Vautherot, JF

Rasschaert, D

Laurent, S

Petit, F

BoucrautBaralon, C

Milon, A

机构：

[1] INRA, MOLEC MICROBIOL LAB, F-31076 TOULOUSE, FRANCE

[2] ECOLE NATL VET TOULOUSE, TOULOUSE, FRANCE

[3] CTR NATL ETUD VET & ALIMENTAIRES, LAB CENT RECH AVICOLE & PORCINE, PLOUFRAGAN, FRANCE

[4] INRA, UNITE VIROL & IMMUNOL MOLEC, JOUY EN JOSAS, FRANCE

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 08期

关键词：

D O I：

10.1128/JVI.70.8.5061-5066.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Two myxoma virus-rabbit hemorrhagic disease virus (RHDV) recombinant viruses were constructed with the SG33 strain of myxoma virus to protect rabbits against myxomatosis and rabbit viral hemorrhagic disease. These recombinant viruses expressed the RHDV capsid proteid (VP60). The recombinant protein, which is 60 kDa in size, was antigenic, as revealed by its reaction in immunoprecipitation with antibodies raised against RHDV. Both recombinant viruses induced high levels of RHDV- and myxoma virus-specific antibodies in rabbits after immunization. Inoculations by the intradermal route protected animals against virulent RHDV and myxoma virus challenges.

引用

页码：5061 / 5066

页数：6

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