Constitutive EGFR signaling confers a motile phenotype to neural stem cells

被引：96

作者：

Boockvar, JA

Kapitonov, D

Kapoor, G

Schouten, J

Counelis, GJ

Bogler, O

Snyder, EY

McIntosh, TK

O'Rourke, DM

机构：

[1] Univ Penn, Sch Med, Dept Neurosurg, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Henry Ford Hosp, Hermelin Brain Tumor Ctr, Detroit, MI 48202 USA

[4] Henry Ford Hosp, Dept Neurosurg, Detroit, MI 48202 USA

[5] Harvard Univ, Sch Med, Dept Neurol, Boston, MA 02115 USA

来源：

MOLECULAR AND CELLULAR NEUROSCIENCE | 2003年 / 24卷 / 04期

关键词：

D O I：

10.1016/j.mcn.2003.09.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The epidermal growth factor receptor (EGFR) has been shown to play an important role in brain development, including stem and precursor cell survival, proliferation, differentiation, and migration. To further examine the temporal and spatial requirements of erbB signals in uncommitted neural stem cells (NSCs), we expressed the ligand-independent EGF receptor, EGFRvIII, in C17.2 NSCs. These NSCs are known to migrate and to evince a tropic response to neurodegenerative environments in vivo but for which an underlying mechanism remains unclear. We show that enhanced erbB signaling via constitutive kinase activity of EGFRvIII in NSCs sustains an immature phenotype and enhances NSC migration. (C) 2003 Elsevier Inc. All rights reserved.

引用

收藏

页码：1116 / 1130

页数：15

相关论文

共 65 条

[1] Neural stem cells display extensive tropism for pathology in adult brain: Evidence from intracranial gliomas [J].

Aboody, KS ;

Brown, A ;

Rainov, NG ;

Bower, KA ;

Liu, SX ;

Yang, W ;

Small, JE ;

Herrlinger, U ;

Ourednik, V ;

Black, PM ;

Breakefield, XO ;

Snyder, EY .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (23) :12846-12851

[2] Epidermal growth factor receptor and Ink4a/Arf:: Convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis [J].

Bachoo, RM ;

Maher, EA ;

Ligon, KL ;

Sharpless, NE ;

Chan, SS ;

You, MJJ ;

Tang, Y ;

DeFrances, J ;

Stover, E ;

Weissleder, R ;

Rowitch, DH ;

Louis, DN ;

DePinho, RA .

CANCER CELL, 2002, 1 (03) :269-277

[3] Response diversity and the timing of progenitor cell maturation are regulated by developmental changes in EGFR expression in the cortex [J].

Burrows, RC ;

Wancio, D ;

Levitt, P ;

Lillien, L .

NEURON, 1997, 19 (02) :251-267

[4] Mechanisms of progenitor maturation are conserved in the striatum and cortex [J].

Burrows, RT ;

Lillien, L ;

Levitt, P .

DEVELOPMENTAL NEUROSCIENCE, 2000, 22 (1-2) :7-15

[5]

Caric D, 2001, DEVELOPMENT, V128, P4203

[6] The glioma-associated protein SETA interacts with AIP1/Alix and AZIG-2 and modulates apoptosis in astrocytes [J].

Chen, B ;

Borinstein, SC ;

Gillis, J ;

Sykes, VW ;

Bogler, O .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (25) :19275-19281

[7] Role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility [J].

Chen, P ;

MurphyUllrich, JE ;

Wells, A .

JOURNAL OF CELL BIOLOGY, 1996, 134 (03) :689-698

[8] Invasion of human glioma biopsy specimens in cultures of rodent brain slices:: a quantitative analysis [J].

de Boüard, S ;

Christov, C ;

Guillamo, JS ;

Kassar-Duchossoy, L ;

Palfi, S ;

Leguerinel, C ;

Masset, M ;

Cohen-Hagenauer, O ;

Peschanski, M ;

Lefrançois, T .

JOURNAL OF NEUROSURGERY, 2002, 97 (01) :169-176

[9] EGF RECEPTOR AND ERBB-2 TYROSINE KINASE DOMAINS CONFER CELL SPECIFICITY FOR MITOGENIC SIGNALING [J].

DIFIORE, PP ;

SEGATTO, O ;

TAYLOR, WG ;

AARONSON, SA ;

PIERCE, JH .

SCIENCE, 1990, 248 (4951) :79-83

[10] EGF converts transit-amplifying neurogenic precursors in the adult brain into multipotent stem cells [J].

Doetsch, F ;

Petreanu, L ;

Caille, I ;

Garcia-Verdugo, JM ;

Alvarez-Buylla, A .

NEURON, 2002, 36 (06) :1021-1034

← 1 2 3 4 5 6 7 →