Therapeutic vaccines for chronic diseases: successes and technical challenges

被引：58

作者：

Bachmann, Martin F. ^{[1
]}

Jennings, Gary T. ^{[1
]}

机构：

[1] Cytos Biotechnol AG, CH-8952 Zuerich Schlieren, Switzerland

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1579期

关键词：

therapeutic vaccines; chronic diseases; smoking cessation vaccine; VIRUS-LIKE PARTICLES; PHASE-I SAFETY; NICOTINE DISTRIBUTION; AUTOIMMUNE ARTHRITIS; PRECLINICAL EFFICACY; ACTIVE IMMUNIZATION; DOUBLE-BLIND; IMMUNOGENICITY; DRUG; HYPERTENSION;

D O I：

10.1098/rstb.2011.0103

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Chronic, non-communicable diseases are the major cause of death and disability worldwide and have replaced infectious diseases as the major burden of society in large parts of the world. Despite the complexity of chronic diseases, relatively few predisposing risk factors have been identified by the World Health Organization. Those include smoking, alcohol abuse, obesity, high cholesterol and high blood pressure as the cause of many of these chronic conditions. Here, we discuss several examples of vaccines that target these risk factors with the aim of preventing the associated diseases and some of the challenges they face.

引用

页码：2815 / 2822

页数：8

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