A novel insulin delivery algorithm in rats with Type 1 diabetes: The fading memory proportional-derivative method

被引：26

作者：

Gopakumaran, B ^{[1
]}

Duman, HM ^{[1
]}

Overholser, DP ^{[1
]}

Federiuk, IF ^{[1
]}

Quinn, MJ ^{[1
]}

Wood, MD ^{[1
]}

Ward, WK ^{[1
]}

机构：

[1] Legacy Clin Res & Technol Ctr, Portland, OR 97232 USA

来源：

ARTIFICIAL ORGANS | 2005年 / 29卷 / 08期

关键词：

artificial pancreas; fading memory; Type; 1; diabetes; performance index; closed-loop algorithm;

D O I：

10.1111/j.1525-1594.2005.29096.x

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An algorithm designed to automatically control insulin delivery was tested in rats with Type 1 diabetes. This nonlinear algorithm included a fading memory component of proportional and derivative errors in order to simulate normal insulin secretion. Error-weighting functions for the proportional and derivative terms were used with a performance index designed for error adaptation. In the first version of the algorithm, the proportional gain was adaptively varied. In the second version, a low rate of basal insulin delivery was adaptively varied. Six 6-h studies with each version were conducted using frequent blood sampling and intravenous insulin delivery. In Version 2 studies, blood glucose levels during the last two hours were well-controlled and significantly lower than in Version 1 (118 +/- 2.0 vs. 130 +/- 2.9 mg/dL). Neither version produced hypoglycemia. Future research using this algorithm needs to focus on automated glucose sensing in combination with insulin delivery.

引用

页码：599 / 607

页数：9

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