Resistance of Pseudomonas aeruginosa to imipenem induced by eluates from siliconized latex urinary catheters is related to outer membrane protein alterations

被引：28

作者：

Martínez-Martínez, L

Pascual, A

Conejo, MD

Picabea, L

Perea, EJ

机构：

[1] Univ Seville, Sch Med, Dept Microbiol, Seville 41080, Spain

[2] Forens Sci Inst, Seville, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1128/AAC.43.2.397

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized Latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase beta-lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.

引用

页码：397 / 399

页数：3

共 23 条

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