Identification of new quantitative trait loci (other than the PRNP gene) modulating the scrapie incubation period in sheep

被引：21

作者：

Moreno, C. R. ^{[1
]}

Cosseddu, G. M. ^{[2
,5
]}

Schibler, L. ^{[2
]}

Roig, A. ^{[2
]}

Moazami-Goudarzi, K. ^{[2
]}

Andreoletti, O. ^{[3
]}

Eychenne, F. ^{[4
]}

Lajous, D.

Schelcher, F. ^{[3
]}

Cribiu, E. P. ^{[2
]}

Laurent, P. ^{[2
]}

Vaiman, D. ^{[2
,6
,7
]}

Elsen, J. M.

机构：

[1] INRA, SAGA, UR Ameliorat Genet Anim 631, BP52627, F-31326 Castanet Tolosan, France

[2] INRA, UR Genet Biochim & Cylogenet 339, F-78352 Jouy En Josas, France

[3] INRA ENV Toulouse, Interact Hotes Agents Pathogenes, F-31076 Toulouse, France

[4] INRA, UE65 Domaine Expt Langlade, F-31450 Montgiscard, France

[5] Ist Super Sanita, Dept Food Safety & Vet Publ Hlth, I-00161 Rome, Italy

[6] INSERM, U567 Inst Cochin, Team 21, F-75014 Paris, France

[7] Univ Paris 05, Fac Med Cochin Port Royale, F-75014 Paris, France

来源：

GENETICS | 2008年 / 179卷 / 01期

关键词：

D O I：

10.1534/genetics.108.088146

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although Susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.

引用

页码：723 / 726

页数：4

共 28 条

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