Kinetics of anhydride formation in xerogels of poly(acrylic acid)

被引：18

作者：

BlancoFuente, H

AnguianoIgea, S

OteroEspinar, FJ

BlancoMendez, J

机构：

[1] Lab. de Farmacia Galénica, Departamento de Farmacología, Farmacia y Tecnologia Farmaceutica

来源：

BIOMATERIALS | 1996年 / 17卷 / 17期

关键词：

Carbopol(R); cross-linking; xerogel; activation energy; reaction kinetics; anhydride formation;

D O I：

10.1016/0142-9612(96)87646-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The aim of this work was to study the cross-linkage of xerogels made of Carbopol(R) of different molecular weight (polymers deriving from polyacrylic acid), and the influence exerted by different percentages of beta-cyclodextrin upon the cross-linkage percentage. Xerogels were obtained by high-pressure compression and cross-linking was studied by measuring the weight loss of different formulations over a temperature range of 70 to 190 degrees C. Kinetics of anhydride formation were found to follow a second-order mechanism with an activation energy of approximately 25 kcal mol(-1). (C) 1996 Elsevier Science Limited

引用

页码：1667 / 1675

页数：9

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