Using BioMart as a framework to manage and query pancreatic cancer data

被引:7
作者
Cutts, Rosalind J. [1 ]
Gadaleta, Emanuela [1 ]
Lemoine, Nicholas R. [1 ]
Chelala, Claude [1 ]
机构
[1] Queen Mary Univ London, Ctr Mol Oncol, Barts Canc Inst, London EC1M 6BQ, England
来源
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION | 2011年
关键词
EXPRESSION DATABASE; INTEGRATION; RESOURCES; PLATFORM;
D O I
10.1093/database/bar024
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We describe the Pancreatic Expression Database (PED), the first cancer database originally designed based on the BioMart infrastructure. The PED portal brings together multidimensional pancreatic cancer data from the literature including genomic, proteomic, miRNA and gene expression profiles. Based on the BioMart 0.7 framework, the database is easily integrated with other BioMart-compliant resources, such as Ensembl and Reactome, to give access to a wide range of annotations alongside detailed experimental conditions. This article is intended to give an overview of PED, describe its data content and work through examples of how to successfully mine and integrate pancreatic cancer data sets and other BioMart resources. Database URL: http://www.pancreasexpression.org
引用
收藏
页数:6
相关论文
共 18 条
[1]  
[Anonymous], 2011, ICGC DAT PORT
[2]   Pancreatic Expression database: a generic model for the organization, integration and mining of complex cancer datasets [J].
Chelala, Claude ;
Hahn, Stephan A. ;
Whiteman, Hannah J. ;
Barry, Sayka ;
Hariharan, Deepak ;
Radon, Tomasz P. ;
Lemoine, Nicholas R. ;
Crnogorac-Jurcevic, Tatjana .
BMC GENOMICS, 2007, 8 (1)
[3]   A Web-Based Platform for Mining Pancreatic Expression Datasets [J].
Chelala, Claude ;
Lemoine, Nicholas R. ;
Hahn, Stephan A. ;
Crnogorac-Jurcevic, Tatjana .
PANCREATOLOGY, 2009, 9 (04) :340-343
[4]   Integration of biological networks and gene expression data using Cytoscape [J].
Cline, Melissa S. ;
Smoot, Michael ;
Cerami, Ethan ;
Kuchinsky, Allan ;
Landys, Nerius ;
Workman, Chris ;
Christmas, Rowan ;
Avila-Campilo, Iliana ;
Creech, Michael ;
Gross, Benjamin ;
Hanspers, Kristina ;
Isserlin, Ruth ;
Kelley, Ryan ;
Killcoyne, Sarah ;
Lotia, Samad ;
Maere, Steven ;
Morris, John ;
Ono, Keiichiro ;
Pavlovic, Vuk ;
Pico, Alexander R. ;
Vailaya, Aditya ;
Wang, Peng-Liang ;
Adler, Annette ;
Conklin, Bruce R. ;
Hood, Leroy ;
Kuiper, Martin ;
Sander, Chris ;
Schmulevich, Ilya ;
Schwikowski, Benno ;
Warner, Guy J. ;
Ideker, Trey ;
Bader, Gary D. .
NATURE PROTOCOLS, 2007, 2 (10) :2366-2382
[5]   Molecular alterations in pancreatic carcinoma: expression profiling shows that dysregulated expression of S100 genes is highly prevalent [J].
Crnogorac-Jurcevic, T ;
Missiaglia, E ;
Blaveri, E ;
Gangeswaran, R ;
Jones, M ;
Terris, B ;
Costello, F ;
Neoptolemos, JP ;
Lemoine, NR .
JOURNAL OF PATHOLOGY, 2003, 201 (01) :63-74
[6]   The Pancreatic Expression database: 2011 update [J].
Cutts, Rosalind J. ;
Gadaleta, Emanuela ;
Hahn, Stephan A. ;
Crnogorac-Jurcevic, Tatjana ;
Lemoine, Nicholas R. ;
Chelala, Claude .
NUCLEIC ACIDS RESEARCH, 2011, 39 :D1023-D1028
[7]   The Distributed Annotation System [J].
Dowell, Robin D. ;
Jokerst, Rodney M. ;
Day, Allen ;
Eddy, Sean R. ;
Stein, Lincoln .
BMC BIOINFORMATICS, 2001, 2 (1)
[8]   COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer [J].
Forbes, Simon A. ;
Bindal, Nidhi ;
Bamford, Sally ;
Cole, Charlotte ;
Kok, Chai Yin ;
Beare, David ;
Jia, Mingming ;
Shepherd, Rebecca ;
Leung, Kenric ;
Menzies, Andrew ;
Teague, Jon W. ;
Campbell, Peter J. ;
Stratton, Michael R. ;
Futreal, P. Andrew .
NUCLEIC ACIDS RESEARCH, 2011, 39 :D945-D950
[9]   Online resources of cancer data: barriers, benefits and lessons [J].
Gadaleta, Emanuela ;
Lemoine, Nicholas R. ;
Chelala, Claude .
BRIEFINGS IN BIOINFORMATICS, 2011, 12 (01) :52-63
[10]   Galaxy: A platform for interactive large-scale genome analysis [J].
Giardine, B ;
Riemer, C ;
Hardison, RC ;
Burhans, R ;
Elnitski, L ;
Shah, P ;
Zhang, Y ;
Blankenberg, D ;
Albert, I ;
Taylor, J ;
Miller, W ;
Kent, WJ ;
Nekrutenko, A .
GENOME RESEARCH, 2005, 15 (10) :1451-1455