International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck

被引：87

作者：

Amit, Moran ^{[1
]}

Binenbaum, Yoav ^{[1
]}

Trejo-Leider, Leonor ^{[2
]}

Sharma, Kanika ^{[3
]}

Ramer, Naomi ^{[4
]}

Ramer, Ilana ^{[4
]}

Agbetoba, Abib ^{[5
]}

Miles, Brett ^{[5
]}

Yang, Xinjie ^{[6
]}

Lei, Delin ^{[6
]}

Bjorndal, Kristine ^{[7
]}

Godballe, Christian ^{[7
]}

Mucke, Thomas ^{[8
]}

Wolff, Klaus-Dietrich ^{[8
]}

Eckardt, Andre M. ^{[9
]}

Copelli, Chiara ^{[10
]}

Sesenna, Enrico ^{[10
]}

Palmer, Frank ^{[11
]}

Ganly, Ian ^{[11
]}

Patel, Snehal ^{[11
]}

Gil, Ziv ^{[1
,12
]}

机构：

[1] Technion Israel Inst Technol, Lab Appl Canc Res, Clin Res Ctr Rambam, Rambam Med Ctr,Rappaport Med Sch, Haifa, Israel

[2] Tel Aviv Med Ctr & Sch Med, Dept Pathol, Tel Aviv, Israel

[3] Lok Nayak Hosp, Dept Radiotherapy & Oncol, New Delhi, India

[4] Mt Sinai Sch Med, Dept Pathol, New York, NY USA

[5] Ichan Sch Med Mt Sinai, Dept Otolaryngol, New York, NY USA

[6] Fourth Mil Med Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Xian, Peoples R China

[7] Odense Univ Hosp Odense, Dept Otolaryngol Head & Neck Surg, Odense, Denmark

[8] Tech Univ Munich, Dept Oral & Maxillofacial Surg, D-80290 Munich, Germany

[9] Hannover Med Sch, Dept Craniomaxillofacial Surg, Hannover, Germany

[10] Univ Hosp Parma, Maxillofacial Surg, Parma, Italy

[11] Mem Sloan Kettering Canc Ctr, Head & Neck Surg Serv, New York, NY 10021 USA

[12] Technion Israel Inst Technol, Rambam Med Ctr, Dept Otolaryngol Head & Neck Surg, Haifa, Israel

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2015年 / 37卷 / 07期

关键词：

adenoid cystic carcinoma; survival; perineural invasion; intraneural invasion; salivary gland; head and neck cancer; CELL-ADHESION MOLECULE; PERINEURAL INVASION; SALIVARY-GLANDS; DISTANT METASTASIS; PANCREATIC-CANCER; NERVE PLEXUS; SKULL BASE; PREDICTORS; RADIATION; PATTERNS;

D O I：

10.1002/hed.23710

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

BackgroundThe purpose of this study was to characterize the incidence, pattern of spread, and prognostic correlation of nerve invasion in patients with adenoid cystic carcinoma (ACC). MethodsUsing 3 different pathological categories of perineural invasion, intraneural invasion, and perineural inflammation, we investigated the prognostic value of nerve invasion in a total of 495 ACCs from 9 international patient cohorts with median follow-up 90 months (range, 12-288 months). ResultsOf 239 patients (48%) with nerve invasion, 174 (73%) had perineural invasion, 65 (27%) intraneural invasion, and 37 (15%) perineural inflammation. Multivariate Cox regression analysis identified tumor site (p = .008; hazard ratio [HR] = 1.8; 95% confidence interval [CI] = 0.07-3.7) and intraneural invasion (p < .001; HR = 5.9; 95% CI = 0.8-12.3) as independent prognostic markers for both overall survival (OS) and disease-specific survival (DSS), but not of distant metastases. ConclusionAlthough perineural invasion has no impact on survival, intraneural invasion is an independent predictor of poor prognosis. Recognition of intraneural invasion may help optimize treatment of patients with head and neck ACC. (c) 2014 Wiley Periodicals, Inc. Head Neck 37: 1038-1045, 2015

引用

页码：1038 / 1045

页数：8

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