Do leptin receptors play a functional role in the endocrine pancreas?

被引：70

作者：

LeclercqMeyer, V

Considine, RV

Sener, A

Malaisse, WJ

机构：

[1] FREE UNIV BRUSSELS,EXPT MED LAB,B-1070 BRUSSELS,BELGIUM

[2] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT MED,PHILADELPHIA,PA 19107

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 229卷 / 03期

关键词：

D O I：

10.1006/bbrc.1996.1882

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

It was recently speculated that leptin may exert a direct inhibitory effect upon insulin release from the pancreatic B-cell. This proposal meets. however, with two objections. First, although the message for leptin receptors is indeed detected in rat pancreatic islets. the short form of this receptor, for which no signalling function is known, represents thr major species present in islet cells. Second, in the isolated perfused rat pancreas, leptin (1.0 nM) fails io affect the release of either insulin or glucagon. (C) 1996 Academic Press

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页码：794 / 798

页数：5

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