IL-4/IL-13 independent goblet cell hyperplasia in experimental helminth infections

被引:48
作者
Marillier, Reece G. [1 ]
Michels, Chesney [1 ]
Smith, Elizabeth M. [1 ]
Fick, Lizette C. E. [1 ]
Leeto, Mosiuoa [1 ]
Dewals, Benjamin [1 ]
Horsnell, William G. C. [1 ]
Brombacher, Frank [1 ]
机构
[1] Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Div Immunol, ZA-7925 Cape Town, South Africa
基金
英国惠康基金;
关键词
D O I
10.1186/1471-2172-9-11
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: Intestinal mucus production by hyperplasic goblet cells is a striking pathological feature of many parasitic helminth infections and is related to intestinal protection and worm expulsion. Induction of goblet cell hyperplasia is associated with TH2 immune responses, which in helminth infections are controlled primarily by IL-13, and also IL-4. In the study presented here we examine the goblet cell hyperplasic response to three experimental parasitic helminth infections; namely Nippostrongylus brasiliensis, Syphacia obvelata and Schistosoma mansoni. Results: As expected N. brasiliensis infection induced a strong goblet cell hyperplasia dependent on IL-4/IL-13/IL-4R alpha expression. In contrast, and despite previously published transiently elevated IL4/IL-13 levels, S. obvelata infections did not increase goblet cell hyperplasia in the colon. Furthermore, induction of goblet cell hyperplasia in response to S. mansoni eggs traversing the intestine was equivalent between BALB/c, IL-4/IL-13(-/-) and IL-4R alpha(-/-) mice. Conclusion: Together these data demonstrate that intestinal goblet cell hyperplasia can be independent of TH2 immune responses associated with parasitic helminth infections.
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页数:9
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