Catalyst-free synthesis of quinazoline derivatives using low melting sugar-urea-salt mixture as a solvent

被引：175

作者：

Zhang, Zhan-Hui ^{[1
]}

Zhang, Xiao-Nan ^{[1
]}

Mo, Li-Ping ^{[1
]}

Li, Yong-Xiao ^{[1
]}

Ma, Fei-Ping ^{[1
]}

机构：

[1] Hebei Normal Univ, Coll Chem & Mat Sci, Shijiazhuang 050024, Peoples R China

来源：

GREEN CHEMISTRY | 2012年 / 14卷 / 05期

基金：

中国国家自然科学基金;

关键词：

MAGNETICALLY SEPARABLE CATALYST; ONE-POT PROCEDURE; ANTIINFLAMMATORY EVALUATION; MULTICOMPONENT REACTIONS; POLYETHYLENE-GLYCOL; ORGANIC-REACTIONS; REACTION MEDIA; EFFICIENT; WATER; HETEROCYCLES;

D O I：

10.1039/c2gc35258c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Low melting mixture of maltose-dimethylurea (DMU)-NH4Cl was found to be an inexpensive, non-toxic, easily biodegradable and effective reaction medium in the catalyst-free synthesis of quinazoline derivatives. This simple and efficient method furnished the corresponding quinazolines in high yields via one-pot three-component reaction of 2-aminoaryl ketones, aldehyde, and ammonium acetate under aerobic oxidation conditions.

引用

页码：1502 / 1506

页数：5

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