Insulin resistance is increased by transdermal estrogen therapy in postmenopausal women with cardiac syndrome X

被引:7
作者
Assali, AR
Jabara, Z
Shafer, Z
Solodky, A
Herz, I
Sclarovsky, E
Strasberg, B
Sclarovsky, S
Fainaru, M
机构
[1] Rabin Med Ctr, Dept Med A, Lipid Res Lab, IL-49100 Petah Tiqwa, Israel
[2] Univ Texas, Sch Med, Div Cardiol, Houston, TX USA
[3] Hermann Hosp, Houston, TX USA
[4] Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel
[5] Rabin Med Ctr, Dept Cardiol, Petah Tiqwa, Israel
关键词
insulin resistance; estrogen replacement therapy; cardiac syndrome x;
D O I
10.1159/000047340
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Estrogen has been reported to have both short- and long-term effects on the cardiovascular system. However, it remains to be examined how short-term transdermal estrogen therapy (TET) affects insulin sensitivity (SI) in patients with cardiac syndrome X (CSX), who are characterized by elevated insulin resistance. SI was assessed in a randomized, double-blind, placebo-controlled crossover study by minimal model analysis in seven postmenopausal women with CSX treated by TET, SI decreased by 32 +/- 8.3%, from 5.94 +/- 1.14 at baseline to 3.61 +/- 0.40 [(10(-4) x min(-1))/(muU/ml)] during TET (p = 0.03). Time to the onset of symptoms increased from 414.2 +/- 51.0 s at baseline to 450.0 +/- 53.2 s (p = 0.04). We conclude that TET increases SI in postmenopausal women with CSX, This effect is unrelated to the beneficial anti-ischemic effects on exercise duration. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码:31 / 34
页数:4
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