Structural, ultrastructural studies and evolution of Trypanosoma cruzi-infected mice treated with thioridazine

被引：11

作者：

Paglini-Oliva, P ^{[1
]}

Fernandez, AR ^{[1
]}

Fretes, R ^{[1
]}

Peslman, A ^{[1
]}

机构：

[1] Univ Nacl Cordoba, Inst Fisiol, Fac Ciencias Med, Catedra Fis Biomed, RA-5000 Cordoba, Argentina

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 1998年 / 65卷 / 02期

关键词：

D O I：

10.1006/exmp.1998.2227

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Thioridazine (THI) is a tricyclic drug that belongs to the phenothiazine series. THI had a lethal effect upon epimastigotes in culture medium in a concentration of 0.5 mu M. Trypanocidal effect upon trypomastigotes of Trypanosoma cruzi was observed above 0.5 mM of THI. Ultrastructural studies showed intracellular vacuoles in both parasite forms and mitochondrion reorganization. To analyze the use of THI as a therapy, male mice were inoculated with 7 . 10(4) trypomastigotes of T. cruzi, Tulahuen strain, and treated with THI for 3 days, with 80 mg/kg/day. Survival and parasitemia of mice treated with lower doses were similar to those observed in the control group (14 days postinfection). THI treatment modified parasitemia levels. They were negative by day 20 p.i. Hearts from control untreated mice presented typical chagasic myocarditis. Hearts from THI-treated mice sacrificed by day 30 p.i. showed inflammatory infiltrates without amastigote nests. Three months postinfection a mild infiltrate located in the interventricular septum was observed. Survival of this group was 9 months. Present results show that THI had a direct effect upon parasitemia, improved survival of treated mice, and modified the evolution of experimental Chagas disease. (C) 1998 Academic Press.

引用

页码：78 / 86

页数：9

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