Calmodulin-dependent protein kinase IV: regulation of function and expression

被引：29

作者：

Krebs, J ^{[1
]}

机构：

[1] ETH Zurich, Inst Biochem 3, CH-8092 Zurich, Switzerland

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1998年 / 1448卷 / 02期

关键词：

calmodulin; calmodulin kinase IV; calmodulin kinase kinase; thyroid hormone T-3; cAMP response element binding protein; immediate early gene; c-fos; CaMKIV-PP2A complex;

D O I：

10.1016/S0167-4889(98)00142-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calmodulin-dependent protein kinase IV (CaMKIV) is a key mediator of Ca2+-induced gene expression. This serine/threonine kinase is itself activated by a calmodulin kinase kinase. In the present contribution the gene structure, regulation of activity, the role in Ca2+-dependent gene expression, and the hormonal induction and controlled expression of CaMKIV during tissue development are reviewed. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：183 / 189

页数：7

共 67 条

[1] Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV
Anderson, KA
Ribar, TJ
Illario, M
Means, AR
[J]. MOLECULAR ENDOCRINOLOGY, 1997, 11 (06) : 725 - 737
[2] EFFECT OF THYROID HORMONE ON BIOCHEMICAL MATURATION OF RAT BRAIN - POSTNATAL CELL FORMATION
BALAZS, R
KOVACS, S
COCKS, WA
JOHNSON, AL
EAYRS, JT
[J]. BRAIN RESEARCH, 1971, 25 (03) : 555 - &
[3] CREB phosphorylation and dephosphorylation: A Ca2(+)- and stimulus duration-dependent switch for hippocampal gene expression
Bito, H
Deisseroth, K
Tsien, RW
[J]. CELL, 1996, 87 (07) : 1203 - 1214
[4] THE CDNA SEQUENCE AND CHARACTERIZATION OF THE CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE-GR FROM HUMAN BRAIN AND THYMUS
BLAND, MM
MONROE, RS
OHMSTEDE, CA
[J]. GENE, 1994, 142 (02) : 191 - 197
[5] Severe impairment of spermatogenesis in mice lacking the CREM gene
Blendy, JA
Kaestner, KH
Weinbauer, GF
Nieschlag, E
Schutz, G
[J]. NATURE, 1996, 380 (6570) : 162 - 165
[6] BRAUN AP, 1995, ANNU REV BIOCHEM, V57, P26512
[7] A unique phosphorylation-dependent mechanism for the activation of Ca2+/calmodulin-dependent protein kinase type IV/GR
Chatila, T
Anderson, KA
Ho, N
Means, AR
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (35) : 21542 - 21548
[8] CALMODULIN PLAYS A PIVOTAL ROLE IN CELLULAR-REGULATION
CHEUNG, WY
[J]. SCIENCE, 1980, 207 (4426) : 19 - 27
[9] STRUCTURE OF CALMODULIN TARGET PEPTIDE COMPLEXES
CLORE, GM
BAX, A
IKURA, M
GRONENBORN, AM
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (06) : 838 - 845
[10] Cohen P, 1988, CALMODULIN MOL ASPEC, V5

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